01Two hundred milligrams is the wake lock, not a 100 mg split story
Intake: name the sleep diagnosis, the 200 mg clock, and the contraceptive month before anyone talks 'focus.'
Shops advertise Provigil as a 100 mg clever-drug split. Uxora files 200 mg because that is the recommended adult dose on the US label for the three approved sleepiness indications. One-hundred-milligram tablets exist. They are a different count, not this lock.
Modafinil promotes wakefulness. It does not replace CPAP, a sleep opportunity, or a diagnosis. Using it to crush an exam week while sleeping four hours is off-label bravado and a poor reason to skip the rash and psychiatric warnings.
Sofia peer-passes timing first. Morning for narcolepsy and OSA. About one hour before a night shift for SWD. A 200 mg swallow at 22:00 before a day job is how people then ask for a hypnotic. That is a mess this desk will not tidy by mail.
Uxora does not dispense. Schedule IV rules at a US pharmacy are the pharmacist's, not a coupon site's. See the fill band on this card for the sourced 200 mg times thirty row.

02Morning narcolepsy versus the shift-work hour
Narcolepsy and OSA residual sleepiness share a morning 200 mg on the label. OSA patients were still supposed to use CPAP in the trials. The tablet is not a permission slip to rack the mask.
Shift-work disorder uses the same milligrams on a different clock: about one hour before the shift starts. If the roster flips, the tablet flips. Leaving it at 08:00 'because that is when I take pills' is how night workers stay wired into the commute home.
Four hundred milligrams as a single daily dose showed up in studies. The label says extra benefit over 200 mg was not consistent. Do not self-raise because a forum swears 400 is the real dose.
Elderly clearance can fall. Severe hepatic impairment needs a lower labeled start (often 100 mg on the product insert). That is a clinician cut, not a reason to buy a splitter and guess.
| File | Label clock | What not to do |
|---|---|---|
| Narcolepsy / OSA | 200 mg morning | Skip CPAP and 'replace' it |
| Shift-work disorder | 200 mg ~1 h before shift | Take it at breakfast on a night roster |
| Exam week, no diagnosis | Not a labeled file | Do not borrow a mate's CIV |
03Hepatic cuts, elderly levels, and the rash clock
Severe hepatic impairment: the insert cuts the dose. Do not keep 200 mg because 'that is the lock.' The lock is the usual adult labeled dose, not a dare in liver failure.
In a small elderly multiple-dose study, plasma levels ran about twice historical younger values. Comedications muddied the picture. Still, start conversations lower in the very old.
Severe renal failure (CrCl at or below 20 mL/min) did not change parent modafinil much in a single-dose study, but the inactive acid metabolite rose about nine-fold. That is a specialist footnote, not a home adjustment.
Sofia Mendes will not diagnose narcolepsy by email. If a reader only wants a study pill, this card is the wrong genre.
Wake-file lines that stay on the card
- 200 mg morning - narcolepsy / OSA residual sleepiness
- 200 mg ~1 h before shift - SWD
- Backup contraception during use and 1 month after
- Stop for serious rash or psychiatric break
- Schedule IV - window rules apply
04What 200 mg will not fix, including a weekend PDE5 plan
Modafinil will not treat obstructive sleep apnea. It will not shorten a fluoxetine washout. It will not make Sildalist 120 safer. Wake drugs and PDE5 combos share only this: both get abused as performance kits.
Alcohol plus a wake tablet is a way to feel capable while impaired. Do not drive on that mix. Portugal emergencies: 112.
Food can delay the peak. For a shift start, a heavy meal right before the tablet can slide the wake effect into the wrong hour. The wake-file memo keeps the clock honest.
Angioedema and multi-organ hypersensitivity are rare and ugly. Fever plus rash plus lymphadenopathy is a hospital story.
| Absorption | Oral tablet; food may delay Tmax. |
|---|---|
| Distribution | Racemic mix; R-enantiomer dominates trough at steady state. |
| Metabolism | Amide hydrolysis plus CYP3A4; sulfone metabolite t½ ~40 h. |
| Excretion | Effective elimination t½ ~15 h after multiple doses; steady state 2-4 days. |
05CYP3A4 induction and the contraceptive month after stop
Modafinil is a weak CYP3A4 inducer in a concentration-related way. Steroidal contraceptives, cyclosporine, midazolam, and triazolam can lose exposure. Ethinyl estradiol AUC fell about 18 percent in a labeled interaction study at 200 then 400 mg.
The practical line: use a backup or a different contraceptive method while taking Provigil and for one month after the last tablet. That month is easy to forget when someone 'only needed it for a night-shift month.'
Modafinil also inhibits CYP2C19. Diazepam, phenytoin, and propranolol can rise. In CYP2D6-poor metabolizers, some SSRIs and tricyclics that lean on 2C19 as a backup path can rise too. If fluoxetine is already on the chart, the pair needs a named owner.
The CYP chip memo is the short list. Carbamazepine, phenobarbital, and rifampin can push the other way and flatten modafinil.
06Who should not treat 200 mg as a focus vitamin
Left-ventricular hypertrophy, mitral-valve prolapse, and recent infarction histories show up as caution piles on wake-stimulant counselling. This docket will not clear a heart. Chest pain after a 200 mg start is 112, not a 'modafinil buzz.'
Severe hepatic impairment needs a labeled cut, often 100 mg on the insert. The Uxora lock stays 200 mg for the usual adult file. Liver failure is not the usual adult file.
Pregnancy data are messy. The contraceptive month exists because steroidal methods can fail. Wanting a pregnancy is a stop-and-plan, not a 'keep 200 and hope.' The CYP chip is the backup sentence.
Kids under 17 are not a home 200 mg project. This card is adult labeled sleepiness.
A borrowed CIV strip for an exam is theft of a controlled tablet plus every warning on this page. We will not bless one night.
07Schedule IV at the window, and the cash row we will quote
Provigil is Schedule IV. Pharmacists can refuse a sketchy out-of-state script. Coupon acceptance varies. That is not this desk being difficult. It is controlled-substance law.
The Uxora lock is generic modafinil 200 mg, thirty tablets. We quote the sourced GoodRx band on that count. We do not invent a 100 mg split price to look cheaper.
Serious rash, including Stevens-Johnson syndrome, has occurred. Stop for blistering, mucosal lesions, or a spreading fever-rash. Psychiatric reactions (mania, hallucinations, suicidal thinking) are labeled. A 'smart drug' culture does not delete them.
Generic modafinil 200 mg x 30, GoodRx Provigil table, 23 June 2026.
Generic modafinil 200 mg, thirty tablets, the Uxora Provigil lock, August 2026. GoodRx lists 200 mg x 30 at $881.37 average retail and $27.70 with a coupon (23 June 2026). Schedule IV - coupon acceptance varies by pharmacist. One-hundred-milligram splits are a different count. Uxora does not dispense.
08Psychiatric breaks and rash clocks that shops skip
Mania, hallucinations, and suicidal thinking are labeled. A 'smart drug' culture treats them as rare enough to ignore. A bipolar history is a specialist conversation before the first 200 mg, not a yes from a cart. If mood is already climbing in week one, that is urgent psychiatry, not a split to 100 mg.
Serious rash including Stevens-Johnson syndrome has occurred. Blistering, mucosal lesions, or a spreading fever-rash are stops. Do not finish a 30-count because the lock said 200 mg is the real dose. Multi-organ hypersensitivity (fever, rash, nodes, odd labs) is a hospital story.
Anxiety and insomnia can be the tablet doing exactly what a poorly timed 200 mg does: wake at the wrong hour. Move the clock with the roster before anyone adds a hypnotic from a drawer. See the wake-file memo.
Headache, nausea, and dry mouth are the ordinary cluster. They are not a reason to double to 400 mg. The label already said extra benefit at 400 was not consistent.
If a reader also holds fluoxetine 10 mg, name the pair on both desks. CYP2C19 inhibition plus a long SSRI tail is a monitoring story, not an energy patch for week-one SSRI fatigue.
09Keep 200 mg tied to a sleep diagnosis
Provigil 200 mg is a labeled wake dose. It is a controlled tablet with a contraceptive footnote and a rash warning. It is not a harmless focus candy and not a partner for an export PDE5 stack.
Change the clock or the milligrams only with the clinician who owns the sleep file. The disclaimer is the last word on what this desk is not.
Pencil the indication on the blister. Morning for narcolepsy or residual OSA sleepiness. About one hour before the shift for SWD. Mixed months follow the duty.
A second 200 mg at midnight is an amateur 400. The label did not show a consistent extra benefit at 400 mg.
OSA trials kept CPAP. The tablet is leftover wake, not a mask replacement.
Backup contraception through one month after the last tablet. Ethinyl estradiol AUC fell about 18 percent in the labeled interaction study.
Cyclosporine troughs can fall. Transplant wants the start date today.
Serious rash and psychiatric breaks are stops. A night-shift culture does not delete them.
Severe hepatic impairment needs a cut, often 100 mg. The lock is the usual adult file, not liver failure.
Borrowed CIV for an exam is not a diagnosis. We will not bless one night.
Fluoxetine plus 200 mg needs named owners. Not an automatic ban. Not a DIY energy fix.
Sofia files the wake card. She does not write a Schedule IV refill.
Sixteen-hour shifts do not write a home 400 mg. The label already spoke to that dose.
Implants, pills, patches, and rings can fail during treatment and for one month after stop.
Anesthesia needs the 200 mg on the list. Midazolam and triazolam can lose exposure.
A weaker week is not a license to double. Named owners, not a forum climb.
The 200 mg morning lock stays unless the sleep clinic writes another clock. A late tablet writes insomnia and does not write a second diagnosis.
Shift-work disorder still uses 200 mg about one hour before the night start. That is not a license to stack a morning 200 on the same calendar day without the clinic.
Schedule IV is not a casual refill. Lost strips still get a new named owner, not a second cart from another shop.
Psychiatric history belongs on the first consult. Irritability and mania flags are stops, not reasons to add a second stimulant at home.
Hepatic impairment can need a lower start. Do not invent that milligram from a comment. The sleep clinic writes it.
This docket will not quote a dollar. A 200 mg tablet is a clock and a method warning, not a sale.
A missed morning 200 mg is usually a skip, not a 4 p.m. makeup. Late tablets write late nights.
Narcolepsy and OSA share the morning lock on this site. Shift-work disorder uses 200 mg about one hour before the night start. Those clocks do not stack on one calendar day without the clinic.
Schedule IV means lost strips still need a named owner. A second shop cart is not a refill and this docket will not invent a dollar for a replacement.
Psychiatric history belongs on the first consult. Irritability, mania flags, and new aggression are stops, not reasons to add a home stimulant.
Severe hepatic impairment can need a lower start. This desk will not invent that milligram. The sleep clinic writes it and keeps the 200 mg lock unless they move it.
Ethinyl estradiol exposure can fall about 18 percent. Backup through treatment and one month after the last 200 mg is the stamp. This docket will not pick the method.
Midazolam, triazolam, and some transplant drugs can lose punch. Put the wake tablet on every pre-op and clinic list. A clean hour at the dentist is not a reason to hide 200 mg.
Auto-induction talk at week six is a clinic question. It is not a home climb to 400 mg. Extra benefit at 400 was not consistent on the label.
This Porto file stays prescribed-online in the SERP sense: a licensed clinician where you live, then a pharmacy. Uxora stops at the card. Sofia Mendes peer-passes. She does not roster your shift from Cedofeita 455.
[email protected] can flag a wrong clock on this page. It cannot become an e-script for 200 mg.
Sources
- DailyMed PROVIGIL (modafinil) tablet label
- Label: 200 mg morning (narcolepsy/OSA); 200 mg ~1 h before shift (SWD); CIV; t½ ~15 h.
- Label: steroidal contraceptives plus one month after stop; CYP3A4 induction; CYP2C19 inhibition.
- Ethinyl estradiol interaction: mean AUC0-24 down ~18% in the labeled study.
Checked against the current label and reviewed by Dr. Sofia Mendes. See Intake, Markup, Peer-pass, File.